Late final month, the EPA accredited a brand new “endlessly chemical” pesticide to be used on meals crops. Isocycloseram is a member of the notorious perfluoroalkyl and polyfluoroalkyl substances (PFAS), a bunch of extremely persistent compounds which have been linked to hormone disruption and an elevated threat of most cancers.
PFAS are also called ‘endlessly chemical compounds’ as a result of they’re bioaccumulative, binding to proteins within the blood, liver, and kidneys — to not point out in water sources and within the soil. Isocycloseram particularly has been related to male reproductive points like lowered testicle measurement and decrease sperm depend1. Regardless of these regarding hyperlinks, the compound has now been accredited to be used by the EPA on meals crops like oranges, tomatoes, almonds, peas, and oats. The chemical can be used to deal with golf programs and lawns.
Approval on a Technicality


On November 26, the EPA revealed a information launch framed as a “reality verify” to justify their approval of the pesticide in query2. The discharge targeted on the truth that as a single fluorinated compound, Isocycloseram doesn’t technically fall below the 2023 EPA PFAS definition established throughout the Biden administration. Whereas this can be the case, it’s a loophole at finest — the Organisation for Financial Co-operation and Improvement defines PFAS as “fluorinated substances that comprise at the least one totally fluorinated methyl or methylene carbon atom3.”
Technicalities apart, Isocycloseram could be categorized as reasonably pervasive, with a half-life of over three years4. Furthermore, it’s recognized to remodel into 40 smaller PFAS chemical compounds like trifluoroacetic acid, which is exponentially extra persistent than Isocycloseram. And like many PFAS-containing pesticides, Isocycloseram can be extremely poisonous to bees and different pollinators.
A Regarding PFAS Pesticide Sample


Isocycloseram is the second PFAS pesticide to be accredited since Trump took workplace, following cyclobutrifluram, which earned approval simply two weeks earlier than. And in additional regarding EPA PFAS information, the administration has plans to approve three extra poisonous pesticides containing endlessly chemical compounds within the coming yr.
“To approve extra PFAS pesticides amid the rising consciousness of the intense, long-term risks from these endlessly chemical compounds is absurdly shortsighted,” stated Nathan Donley, environmental well being science director on the Heart for Organic Range. “The plain actuality is that the Trump administration is knowingly placing the nation’s kids at better threat of growing severe reproductive and liver harms for generations to return.”
Sources:
- https://downloads.rules.gov/EPA-HQ-OPP-2021-0641-0015/content material.pdf
- https://www.epa.gov/newsreleases/fact-check-epa-debunks-false-claims-agency-recently-approved-forever-chemical
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10827356/
- https://cen.acs.org/setting/pesticides/4-new-pesticides-ignite-debate/103/internet/2025/06
